ABSTRACT
OBJECTIVE: To describe the clinical characteristics and outcomes of CVT in patients with history of recent COVID-19 infection or vaccination. METHODS: We reviewed demographic, clinical, and radiographic characteristics of non-pyrogenic, non-traumatic CVT cases at our multi-center institution between March 2020 and December 2021. Patients were grouped according to their history of recent COVID-19 infection or vaccination into group-I (+COVID-19 association) and group-II (-COVID-19 association). RESULTS: Fifty-one patients with CVT were included, of which 14 (27.4%) had a positive COVID-19 association: 10 with infection and 4 with mRNA-COVID-vaccine. Nine patients in group-I had COVID-19 infection or vaccine within 30 days of CVT diagnosis, including 3 patients with active infection at the time of CVT diagnosis. Half of the patients in group-I (n = 7,50.0%) and 32.4% (n = 12) of group-II were male, and mean age was 52.6 years in group-I and 51.4 years in group-II. Fever at presentation was noted in one patient who had active COVID infection (I=1 (7.1%), II= 0 (0%)). Higher rates of comorbidities were observed in group-II: hypertension (I= 2 (14.3%), II= 13 (35.1%)), deep venous thrombosis(I=1(7.1%), II= 10 (27.0%)), pulmonary emboli (I=1(7.1%), II= 8(21.6%)), or stroke(I=0(0%), II= 6(16.4%)). Three patients had thrombocytopenia at the time of CVT diagnosis (5.4%) and most patients (n = 37, 72.5%) were treated medically with anticoagulation. Complication rate during hospitalization was 17.6% (n = 6), and no mortality was noted. CONCLUSION: Twenty-seven percent of CVT patients were associated with COVID-19 infection or vaccination, and the majority presented within 30 days of infection/vaccination.
Subject(s)
COVID-19 , Intracranial Thrombosis , Vaccines , Venous Thrombosis , COVID-19/complications , COVID-19/epidemiology , Female , Humans , Intracranial Thrombosis/etiology , Male , Middle Aged , Multicenter Studies as Topic , Pandemics , Venous Thrombosis/epidemiology , Venous Thrombosis/etiologyABSTRACT
Advances in computer science have transformed the way artificial intelligence is employed in academia, with Machine Learning (ML) methods easily available to researchers from diverse areas thanks to intuitive frameworks that yield extraordinary results. Notwithstanding, current trends in the mainstream ML community tend to emphasise wins over knowledge, putting the scientific method aside, and focusing on maximising metrics of interest. Methodological flaws lead to poor justification of method choice, which in turn leads to disregard the limitations of the methods employed, ultimately putting at risk the translation of solutions into real-world clinical settings. This work exemplifies the impact of the problem of induction in medical research, studying the methodological issues of recent solutions for computer-aided diagnosis of COVID-19 from chest X-Ray images.
ABSTRACT
En este artículo se examinan las relaciones entre los empresarios organizados y el presidente Andrés Manuel López Obrador durante la pandemia de coronavirus. El tema es relevante porque el periodo está marcado por un fuerte deterioro y confrontación entre ambos actores en un momento especialmente neurálgico. Los principales temas que se tratan son: a) la cancelación de la construcción de la cervecería Constellation Brands;b) la carta del presidente López Obrador al presidente del Consejo Coordinador Empresarial, en la que le solicita ayuda para cobrar a empresarios deudores del Servicio de Administración Tributaria, y la respuesta de éste;c) la reacción a las medidas sanitarias y económicas del gobierno para enfrentar la crisis;d) el surgimiento del Frente Nacional AntiAndrés Manuel López Obrador;e) el anuncio de un plan de apoyo financiero del Consejo Mexicano de Negocios y el programa del Banco Interamericano de Desarrollo, bid Invest, y f) el llamado Acuerdo de Confiabilidad de la Secretaría de Energía, que frena el desarrollo de energías renovables.Alternate abstract:This text examines the relationships between organized businessmen and President Andrés Manuel López Obrador during the coronavirus pandemic. The topic is relevant because the period is marked by a strong deterioration and confrontation between both actors at a particularly nerve-wracking moment. The main topics discussed are: a) the cancellation of the construction of the Constellation Brands brewery;b) the letter from President López Obrador to the president of the Business Coordinating Council in which he requests help to collect from debtors of the Treasury Office, and his response;c) the reaction to the government's sanitary and economic measures to face the crisis;d) the emergence of the National Anti-Andres Manuel Lopez Obrador Front;e) the announcement of a financial support plan for the Mexican Business Council and the Inter-American Development Bank program ibd Invest;f) the so-called Reliability Agreement of the Ministry of Energy, that stops the development of renewable energy.